What Role Does CBG Play In The Entourage Effect Of Cannabis?

What Role Does CBG Play In The Entourage Effect Of Cannabis?

May 9, 2024 | Product Guide | By Dave McShane

CannabisCBGEntourage Effect

CBG, or cannabigerol, is a lesser-known cannabinoid found in cannabis that is gaining attention for its potential role in the entourage effect. This phenomenon refers to the synergistic interaction between various compounds in cannabis, such as cannabinoids, terpenes, and flavonoids, that may enhance the therapeutic benefits and effects of the plant. While THC and CBD often take the spotlight, CBG has been hailed for its unique properties and potential health benefits. Research suggests that CBG may possess anti-inflammatory, antibacterial, neuroprotective, and appetite-stimulating properties. By understanding the role CBG plays in the entourage effect, we can gain a deeper insight into how different compounds in cannabis work together to provide a holistic therapeutic experience.

Key Takeaways:

  • CBG contributes to the entourage effect: CBG is thought to enhance the entourage effect by working synergistically with other cannabinoids, such as THC and CBD, potentially boosting the overall therapeutic benefits of cannabis.
  • CBG offers unique therapeutic properties: CBG has shown promising medicinal properties, including anti-inflammatory, neuroprotective, and analgesic effects, making it a valuable component in promoting the entourage effect of cannabis.
  • Understanding the entourage effect is key: Recognising the importance of CBG and other cannabinoids interacting together in the entourage effect sheds light on the complexity and potential benefits of whole-plant cannabis medicine, emphasising the significance of using full-spectrum products over isolated compounds.

Understanding CBG

The Science of Cannabigerol (CBG)

Little is known about cannabigerol (CBG) in comparison to its more famous counterparts like THC and CBD. CBG is considered a minor cannabinoid, present at low levels in most cannabis strains. It is often called the “stem cell” or “parent cannabinoid” because it is the precursor to other cannabinoids.

CBG vs. Other Cannabinoids

The role of CBG in the entourage effect is gaining attention in the cannabis community. Studies suggest that CBG may have unique therapeutic properties that differentiate it from other cannabinoids. For example, CBG has been found to have potential anti-inflammatory, neuroprotective, and anti-cancer effects. More research is needed to fully understand the capabilities of CBG and how it interacts with other cannabinoids in the entourage effect.

A microscopic depiction Showing THC molecules binding to a part of the ECS (Endocannabinoid System). This show cells of many varying colours to include blue, purple, bright green and orange.

CBG’s Role in the Entourage Effect

While much attention has been given to THC and CBD in the world of cannabis research, cannabigerol (CBG) is emerging as a key player in the entourage effect. This lesser-known cannabinoid is beginning to reveal its potential to enhance the therapeutic effects of cannabis when combined with other cannabinoids and terpenes.

Synergistic Interactions with THC and CBD

Effect: CBG has been shown to enhance the effects of THC and CBD when combined in what is known as the entourage effect. This means that CBG can amplify the therapeutic benefits of these cannabinoids when they are used together, potentially leading to more potent and effective outcomes for users.

Modulation of Cannabis Pharmacology

Modulation:  With its ability to modulate the pharmacology of cannabis, CBG can influence how other cannabinoids interact with the body’s endocannabinoid system. This modulation can lead to a more balanced and nuanced effect, potentially reducing the negative side effects of THC while enhancing the positive effects of CBD.

Black 10ml dropper bottle standing upright showing gold coloured writing that states CBG of strength 1000mg by Incr-edibles CBD.

Benefits and Potential of CBG

Therapeutic Benefits Attributed to CBG

Now, let’s research the therapeutic benefits of CBG, also known as cannabigerol. This cannabinoid has shown promising potential in treating various conditions, including inflammation, pain, and even neurodegenerative diseases. Studies suggest that CBG may have anti-inflammatory, antioxidant, and neuroprotective properties, making it a valuable compound in the world of medicinal cannabis.

Research and Limitations

Potential research on CBG is ongoing, but there are limitations to be aware of. An area that requires further exploration is the interaction between CBG and other cannabinoids. Understanding how CBG works synergistically with THC, CBD, and other compounds in the entourage effect is crucial for maximizing its therapeutic potential. Additionally, there is a lack of human clinical trials on CBG, which hinders the development of targeted therapies using this cannabinoid.

Summing up

Hence, CBG plays a crucial role in the entourage effect of cannabis by interacting with other cannabinoids and enhancing their effects. As a precursor to other cannabinoids, CBG has shown great potential in providing therapeutic benefits and contributing to the overall synergy of cannabis compounds. Understanding the role of CBG in the entourage effect is imperative for maximising the medicinal properties of cannabis and developing more effective and diverse products for medical use.


What is CBG?

CBG, or cannabigerol, is a non-psychoactive cannabinoid found in cannabis. It is a precursor to other cannabinoids, such as THC and CBD, as the parent molecule that enzymatically converts into these compounds.

How does CBG contribute to the entourage effect of cannabis?

CBG plays a crucial role in the entourage effect of cannabis by interacting with other cannabinoids, such as THC and CBD, as well as terpenes. These interactions are believed to enhance the overall therapeutic effects of cannabis by working together synergistically rather than in isolation.

What are the potential benefits of CBG in the entourage effect?

A: CBG has been studied for its potential anti-inflammatory, anti-anxiety, and neuroprotective properties. When combined with other cannabinoids and terpenes in the entourage effect, CBG may offer a broader range of therapeutic benefits than other isolated cannabinoids.